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CANNANADA PRODUCTS cannanada KIM-SIMM

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The background is to honor my little Angel part Maltese and Bichon who passed in 2022 in my arms. She went over the Rainbow bridge. I know when you become attached to your animals it's devastating when they leave too soon. They are always in your heart and soul she was very special my therapy doggie we were always together. A poem about Angel and Bella I wrote in 2014 

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In order to bring these benefits to a growing number of individuals through open distribution, Cannanda's research and development has transformed the best-selling CB2™ Wellness blend into a product for dogs. By harnessing the power of terpenes in this precisely formulated blend, we can optimize the function of your dog's endocannabinoid system (ECS) through the activation of one of its main receptors, a receptor called cannabinoid receptor type 2 (CB2).Activating the CB2 ReceptorCB2 is one of the two main receptors of the ECS. There are numerous benefits to activating this receptor without activating the CB1 receptor (the receptor THC activates, and is responsible for the "high" associated with cannabis). The following is a small list of studies illustrating the benefits of CB2 activation.

Hemp Oil for Dogs

Pain & Inflammation:

  • The CB2 receptor and its role as a regulator of inflammation (Cell Mol Life Sci. 2016; 73(23): 4449-70.)

  • Targeting CB2 receptors and the endocannabinoid system for the treatment of pain (Brain Res Rev. 2009 Apr; 60(1): 255-266.)

  • Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain (Br J Pharmacol. 2008 Jan; 153(2): 319–334.)

  • The central cannabinoid receptor type-2 (CB2) and chronic pain. (Int J Neurosci. 2017 Sep;127(9):812-823.)

Anxiety

  • Anxious behavior induces elevated hippocampal CB2 expression. (Neuroscience. 2017 Jun 3;352:273-284.)

  • Regulatory role of the CB2 receptor in stress-induced neuroinflammation. (Br J Pharmacol. 2014 Jun;171(11):2814-26.)

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We give our furry Babies the CB2 oil with their treat or in their food. Also the Dog Ease we give mostly to Rainbow who is full of anxiety. Bella being an older dog she gets some too and we can't leave Willow out. They all get their other AminoBooster either on a plastic spoon or in their food. unfortunately we will not be able to get the Health Evolution soon. No worry will find what we need wanting to keep them healthy and strong. I don't want them to go through what my little Angel endured. I couldn't go through that again.

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All The products we give our furry babies have been clinically tested and studied are pure. Both companies are run by awesome beautiful souls. 

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A NATURAL AND EFFECTIVE TREATMENT FOR PAIN AND ANXIETY IN DOGS
The most common way to use is as follows:

 

CB2 Dog-Ease Hemp Seed Oil: taken daily poured over their food

 

CB2 Dog-Ease terpenes: use as needed by placing drops on their favourite treat. This can also be used topically for wounds, injuries, arthritis, bug bites, hot spots, etc.

This is the one I would recommend if only wanting to use is as needed. We've got plenty of great testimonials for stress and anxiety, but it's important to know that it doesn't have a lot of effect on "normal" hyperactivity. Activation of CB2 receptors essentially helps balance things when they are off balance. If a young puppy is hyper (which is a normal part of their growth and development), our product won't do much. In this case, behavioral training is the better approach, but if it's due to anxiety, then our product could help.

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What does anxiety look like in our pets?

Symptoms of dog anxiety include:

  • Pacing

  • Panting

  • Whimpering

  • Trembling

  • Aggression

  • Urinating or defecating on the floor despite being house trained

  • Nervous licking of the lips

  • Loss of appetite

 

Other symptoms include a loss or reduction of appetite, weight loss, excessive vocalization, lethargy and restlessness. Thankfully, Cannanda’s Dog-Ease CB2™ products can work on all of these symptoms and give your dog some much-needed relief.

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Even if they’re getting great results from CBD, however, adding CB2™ can help get the same results at a smaller dose of CBD. Overall, this can help save you money. Since the end benefits of CB2™ and CBD are very comparable, switching solely to CB2™ could bring about the same results at a fraction of the cost.

Further, from a safety point-of-view, toxicology data for CBD in dogs is still sparse, which is why many veterinarians still do not officially endorse CBD products. Terpenes, on the other hand, have a long history of use in various animals and approved for used in feed for various reasons. The safety of these terpenes in dogs is well-documented, which is not something we can say for CBD, and as mentioned earlier, Dog-Ease CB2™ specifically avoids the use of problematic terpenes.

Lastly, in Canada, CBD is regulated under the Cannabis Act. This means it’s still a criminal offence to buy or sell CBD unless through a government-licensed cannabis dispensary—and these legal products do not offer a suitable version for our furry companions, leaving consumers to look to the black market dispensaries and black market CBD brands for their needs.

Enhance Your Dog's CBD Experience™
Dog-Ease CB2™ can also greatly enhance the benefits your dog already receives from CBD products. Here's how:

  • Activating CB2 receptors is not how CBD is thought to work. This is because CBD only has a very weak ability to bind to CB2 receptors.

  • Newer studies suggest CBD may influence cannabinoid receptor shape and/or inhibit the proteins that remove their endocannabinoids. This means their own endocannabinoids can then activate CB2 receptors, and could be how they get the benefits from CBD products.

  • However, if we can supply the body with external sources of compounds that directly activate CB2 receptors (such as those found in our Dog-Ease CB2™ blend, we can amplify those benefits. It's actually the perfect combination!


Ingredients
Cannanda's proprietary CB2™ terpene blend (100% natural terpenes extracted from botanical sources).
Contains NO: animal by-products, wheat/gluten, dairy/lactose, soy, corn, sugar, GMO, artificial flavours or colours.

Suggested Uses
Dogs & Horses: Use 1 drop for every 25 lbs of body weight. Mix into food just prior to consuming. May be used topically for targeted local relief.
Cats: Since cats metabolize terpenes much slower than humans, dogs, or horses, we only recommend using this blend with an aromatherapy diffuser. Place a couple drops in your ultrasonic diffuser like you would with any essential oil and place close by your 

 

 

Degenerative neurological conditions:

  • Targeting cannabinoid CB2 receptors in the central nervous system. Medicinal chemistry approaches with focus on neurodegenerative disorders (Front Neurosci. 2016; 10: 406.)

  • Central CB2 receptors in inflammation-driven neurodegeneration: dysregulation and therapeutic potential (Neural Regen Res. 2016 Sep; 11(9): 1409–1410.)

  • CB2 receptor: Potential role in immunomodulation and neuroinflammation (J Neuroimmune Pharmacol. 2013 Jun; 8(3): 608-620.)

  • Cannabinoid CB2 receptors in human brain inflammation (Br J Pharmacol. 2008 Jan; 153(2): 277–285.)

Alzheimer's Disease

  • CB2 cannabinoid receptor as potential target against Alzheimer’s Disease (Front Neurosci. 2016; 10: 243.)

Osteoarthritis:

  • Cannabinoid CB2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint (PLoS One. 2013; 8(11): e80440.)

  • Expression of cannabinoid receptors in human osteoarthritic cartilage: Implications for future therapies (Cannabis Cannabinoid Res. 2016 Jan 1;1(1):3-15)

Rheumatoid arthritis:

  • CB2 as a potential therapeutic target in rheumatoid arthritis (Musculoskeletal Disorders. 2014; 15: 275.)

  • CB2 and its inhibitory effects on synovial fibroblasts in rheumatoid arthritis (Rheumatology. 2014; 53(5): 802-809.)

  • Role of CB2 in mediating inflammation in rheumatoid arthritis synovial fibroblasts. (Clin Exp Rheumatol. 2019 Nov-Dec;37(6):1026-1035.)

Immune system modulation:

  • CB2: Potential role in immunomodulation and neuroinflammation (J Neuroimmune Pharmacol. 2013 Jun; 8(3): 608-620.)

  • Emerging role of the CB2 cannabinoid receptor in immune regulation and therapeutic prospects (Expert Rev Mol Med. 2009 Jan 20; 11: e3.)

Cardiovascular:

  • CB2 drives neurogenesis and improves functional outcome after stroke (Stroke. 2017 Jan;(48)1:204-212.)

  • Prospects for creation of cardioprotective drugs based on cannabinoid receptor agonists (J Cardiovasc Pharmacol Ther. 2016 May;21(3):262-72.)

  • CB2 in atherosclerosis and acute cardiovascular diseases (Curr Med Chem. 2014;(21)35:4046-58.)

  • CB2 receptor stimulation attenuates the initiation and progression of atherosclerosis. (Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2210-8.)

  • Time-Dependent Protection of CB2 Receptor Agonist in Stroke. (PLoS One. 2015 Jul 17;10(7):e0132487.)

  • Selective Modulator of CB2 Reduces Memory Impairment and Infarct Size During Cerebral Hypoperfusion and Vascular Dementia. (Curr Neurovasc Res. 2016;13(4):289-302.)

  • The Endocannabinoid System and Heart Disease: The Role of CB2. (Cardiovasc Hematol Disord Drug Targets. 2018;18(1):34-51.)

Metabolic Disorders:

  • CB2 receptor agonist improves systemic sensitivity to insulin (Cell Physiol Biochem. 2016;40(5):1175-1185.)

  • Anti-Obesity Effect of a CB2 Receptor Agonist in Diet-Induced Obese Mice. (PLoS One. 2015 Nov 20;10(11):e0140592.)

Digestive Disorders:

  • CB2 receptor-induced relief of hypermotility in a rat model of the irritable bowel syndrome (Neurogastroenterol Motil. 2019 Jun;31(6):e13613.)

  • Cannabinoids and intestinal motility: welcome to CB2 receptors. (Br J Pharmacol. 2004 Aug;142(8):1201-2.)

Skin Health:

  • CB2 exerts antifibrotic effects in experimental dermal fibrosis. (Arthritis Rheum. 2009 Apr;60(4):1129-36.)

Respiratory Health:

  • CB2 agonist prevents nicotine induced lung fibrosis. (Exp Lung Res. 2018 Sep;44(7):344-351.)

Eye Health

  • Inflammation and CB2 signaling drive novel changes in the ocular lipidome and regulate immune cell activity in the eye. Prostaglandins Other Lipid Mediat. 2018 Nov;139:54-62.

  • CB2 receptors are upregulated with corneal injury and regulate the course of corneal wound healing. Exp Eye Res. 2019 May;182:74-84.

  • Activation of CB2 by selective agonists regulates the deposition and remodelling of the extracellular matrix. Biomed Pharmacother. 2017 Nov;95:1704-1709.

  • CB2 receptor is a novel anti-inflammatory target in experimental proliferative vitreoretinopathy. Neuropharmacology. 2017 Feb;113(Pt B):627-638.

  • CB2 receptor activation reduces leukocyte adhesion and improves capillary perfusion in the iridial microvasculature during systemic inflammation. Clin Hemorheol Microcirc. 2015;61(2):237-49.

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